Yes, you can make a police report if someone is making false accusations or spreading rumors that you are a criminal. Defamation, which is the act of making false statements about someone that harm their reputation, is a crime in many countries.
You can provide the police with any evidence you have to prove that the accusations are false, such as witness statements, emails or text messages, or other documentation. The police will investigate the matter and may take action against the person who made the false accusations.
It's important to remember that making a false police report is also a crime, so be sure that you have evidence to support your claim before making a report.